Information and Communication technologies (ICTs) in marginalized communities act as a link that connects community members to the information that they need. This paper represents an underway research which aims at developing an e-health portal for a multipurpose communication centre for the Siyakhula Living Lab (SLL) project. SLL is an Information and Communication Technologies for Development (ICT4D) project that is undertaken in Dwesa rural area. Dwesa is a rural area that is located in the province of Eastern Cape in South Africa, former Transkei. The portal aims to eliminate the lack of useful and relevant health information in this community by facilitating health knowledge delivery over the web. This research seeks to accomplish these requirements by developing an e-health portal that will make browsing of health resources from the Internet and the Department of Health easy. This portal will accomplish this by facilitating knowledge sharing between clinic nurses and community members. In addition we seek to make use of combination of semantic web tools and develop a medical ontology as part of this portal. This medical ontology will act as information repository for the local knowledge. The initial ontology will be constructed from traditional medical information that will be collected from an Isixhosa traditional doctors and practitioners. Then the system users will also be allowed to add indigenous knowledge that will be approved by administrator. We seek to accomplish the development and implementation of this portal by making use of combination of Free and/or Open Sources such as LAMP, Protégé and RAP.